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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RAPGEF1 All Species: 22.12
Human Site: S489 Identified Species: 54.07
UniProt: Q13905 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13905 NP_005303.2 1077 120548 S489 P S Q Y D N I S G E D L Q S T
Chimpanzee Pan troglodytes XP_001167771 1077 120453 S489 P S Q Y D N I S G E D L Q S T
Rhesus Macaque Macaca mulatta XP_001105413 1095 122595 S507 P S Q Y D N I S G E D L Q S T
Dog Lupus familis XP_548407 1288 143146 S649 P S Q Y D N I S E D D L Q N P
Cat Felis silvestris
Mouse Mus musculus P27671 1262 144083 H667 D F L N T F L H S Y R V F T N
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506600 1390 155369 S657 P S Q Y D N I S E D D L Q N P
Chicken Gallus gallus XP_415456 1091 122977 S503 P S Q Y D N I S E D D M Q N A
Frog Xenopus laevis NP_001085772 1035 117343 L467 T S P F V A V L P F Q P G N T
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O77086 1571 172053 C786 I S S S S S S C T T T T T S S
Honey Bee Apis mellifera XP_393346 1176 130178 S519 L E K L E M E S I S T S D A N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 95.8 75.1 N.A. 20.4 N.A. N.A. 69.5 84.6 77.4 N.A. N.A. 28 34.5 N.A. N.A.
Protein Similarity: 100 99.6 96.3 78.8 N.A. 38.5 N.A. N.A. 72.3 89.6 84.1 N.A. N.A. 43.2 51.2 N.A. N.A.
P-Site Identity: 100 100 100 73.3 N.A. 0 N.A. N.A. 73.3 66.6 13.3 N.A. N.A. 13.3 6.6 N.A. N.A.
P-Site Similarity: 100 100 100 86.6 N.A. 20 N.A. N.A. 86.6 86.6 33.3 N.A. N.A. 26.6 26.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 0 0 0 0 0 0 0 10 10 % A
% Cys: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 0 60 0 0 0 0 30 60 0 10 0 0 % D
% Glu: 0 10 0 0 10 0 10 0 30 30 0 0 0 0 0 % E
% Phe: 0 10 0 10 0 10 0 0 0 10 0 0 10 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 30 0 0 0 10 0 0 % G
% His: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % H
% Ile: 10 0 0 0 0 0 60 0 10 0 0 0 0 0 0 % I
% Lys: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 10 0 10 10 0 0 10 10 0 0 0 50 0 0 0 % L
% Met: 0 0 0 0 0 10 0 0 0 0 0 10 0 0 0 % M
% Asn: 0 0 0 10 0 60 0 0 0 0 0 0 0 40 20 % N
% Pro: 60 0 10 0 0 0 0 0 10 0 0 10 0 0 20 % P
% Gln: 0 0 60 0 0 0 0 0 0 0 10 0 60 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % R
% Ser: 0 80 10 10 10 10 10 70 10 10 0 10 0 40 10 % S
% Thr: 10 0 0 0 10 0 0 0 10 10 20 10 10 10 40 % T
% Val: 0 0 0 0 10 0 10 0 0 0 0 10 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 60 0 0 0 0 0 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _